Obata F, Tsuda-Sakurai K, Yamazaki T, Nishio R, Nishimura K, Kimura M, Funakoshi M, *Miura M.

Nutritional control of stem cell division through S-adenosylmethionine in Drosophila intestine.

Developmental Cell 44, 741-751, 2018

Kosakamoto H, Fujisawa Y, Obata F, *Miura M.

High expression of A-type lamin in the leading front is required for Drosophila thorax closure.

Biochemical and Biophysical Research Communications 499, 209-214, 2018

Obata F, Fons CO, *Gould AP.

Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.

Nature Communications 9, 975, 2018

Stefana IM, Driscol P, Obata F, Pengelly AR, MacRae J, *Gould AP.

Developmental diet regulates Drosophila lifespan via lipid autotoxins.

Nature Communications 8, 1384, 2017


Kashio S, *Obata F, *Miura M.

How tissue damage MET metabolism: Regulation of the systemic damage response.

Fly 11, 27-36, 2017


Kashio S, *Obata F, Zhang L, Katsuyama T, Chihara T, *Miura M.

Tissue nonautonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila.

Proceedings of the National Academy of Sciences 113, 1835-1840, 2016


Shinoda N, Obata F, Zhang L, *Miura M.

Drosophila SETDB1 and caspase cooperatively fine-tune cell fate determination of sensory organ precursor.

Genes to Cells 21, 378-386, 2016


Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Fukamizu A, Noda M, Miura M, *Urano Y.

Detection of LacZ-positive cells in living tissue with single-cell resolution.

Angewandte Chemie International Edition 55, 9620-9624, 2016


Obata F, *Miura M.

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.

Nature Communications 6, 8332, 2015


Obata F, Tanaka S, Kashio S, Tsujimura H, *Sato R, *Miura M.

Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.

BMC Biology 13, 48, 2015


Obata F, Kuranaga E, Tomioka K, Ming M, Takeishi A, Chen CH, Soga T, *Miura M.

Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.

Cell Reports 7, 821-833, 2014


Ming M, Obata F, Kuranaga E, *Miura M.

Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.

Journal of Biological Chemistry 289, 7558-7568, 2014



Kashio S, Obata F, *Miura M.

Interplay of cell proliferation and cell death in Drosophila tissue regeneration.

Development, growth & differentiation 56, 368-375, 2014


Obata F, Tomioka K, *Miura M.

Transcriptional profiling of apoptosis-deficient Drosophila mutants.

Genomics Data 2, 254-257, 2014


Shiraki N, Shiraki Y, Tsuyama T, Obata F, Miura M, Nagae G, Aburatani H, Kume K, Endo F, *Kume S.

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Cell Metabolism 19, 780-794, 2014


Ichikawa Y, Kamiya M, Obata F, Miura M, Terai T, Komatsu T, Ueno T, Hanaoka K, Nagano T, *Urano Y.

Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.

Angewandte Chemie International Edition 53, 6772-6775, 2014


Obata F, Kitami M, Inoue Y, Atsumi S, Yoshizawa Y, *Sato R.

Analysis of the region for receptor binding and triggering of oligomerization on Bacillus thuringiensis Cry1Aa toxin.

FEBS Journal 276, 5949-5959, 2009



日本語総説 (Review article in Japanese)


メチオニン代謝と飢餓応答、The Lipid 26, 61-66, 2015



局所的なネクローシス細胞が引き起こす全身性炎症と代謝異常、ファルマシア51, 556-560, 2015



生体の科学 62, 249-256, 2011


炎症と免疫 18, 222-227, 2010

© 2018 by Fumiaki Obata.



Obata Group in the Department of Genetics,

Graduate School of Pharmaceutical Sciences,

The University of Tokyo